Heather D. VanGuilder Starkey, William E. Sonntag and Willard M. Freeman Increased hippocampal NgR1 signaling machinery in aged rats with deficits of spatial cognition European Journal of Neuroscience 37
Hippocampal expression of NgR1 co-receptors (LINGO-1, p75, TROY) is upregulated in a rodent model of age-related cognitive decline and correlates significantly with spatial learning and memory ability. NgR1 and NgR1 co-receptors are co-expressed by hippocampal neurons in aged cognitively impaired rats, and NgR1 pathway component expression accurately classifies rats by cognitive status. These data suggest that signaling through NgR1 co-receptors may play a causative role in cognitive decline.
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