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Bianca Marchetti, Francesca L'Episcopo, Maria Concetta Morale, Cataldo Tirolo, Nuccio Testa, Salvo Caniglia, Maria Francesca Serapide and Stefano Pluchino Uncovering novel actors in astrocyte–neuron crosstalk in Parkinson's disease: the Wnt/β-catenin signaling cascade as the common final pathway for neuroprotection and self-repair European Journal of Neuroscience 37

Article first published online: 5 MAR 2013 | DOI: 10.1111/ejn.12166

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In this review, the contribution of reactive astrocytes and their ability to modulate midbrain dopaminergic neurodegeneration, neuroprotection and neurorepair in MPTP rodent model of Parkinson's disease (PD) will be discussed in the light of novel emerging evidence implicating Wingless-type MMTV integration site (Wnt)/β-catenin signaling as a strong a candidate in MPTP-induced nigrostriatal dopaminergic plasticity, with implications for identifying new potential therapeutic targets in PD.

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