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L. K. Friedman, J. Mancuso, A. Patel, V. Kudur, J. R. Leheste, S. Iacobas, J. Botta, D. A. Iacobas and D. C. Spray Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy European Journal of Neuroscience 38

Version of Record online: 4 APR 2013 | DOI: 10.1111/ejn.12168

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Injury of the CA1 subregion induced by a single injection of kainic acid (1×KA) is attenuated when juvenile animals (P20) have a history of two sustained neonatal seizures on P6 and P9. To identify gene candidates involved in the spatially protective effects produced by early life conditioning seizures we profiled and compared the transcriptomes of CA1 subregions from control, 1×KA, and 3×KA treated animals.

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