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Paul L. Gabbott and Edmund T. Rolls Increased neuronal firing in resting and sleep in areas of the macaque medial prefrontal cortex European Journal of Neuroscience 37

Version of Record online: 31 MAR 2013 | DOI: 10.1111/ejn.12171

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Neurophysiological recordings of single cells in monkey medial prefrontal cortex (mPFC) identified two cell populations whose mean firing rates altered significantly on eye-closure (sleep). The main finding is that Type 1 cells significantly increased their mean firing rate from 3.1 spikes/s when awake to 10.2 spikes/s when asleep (P«0.01). The data thus identify a substantial population of mPFC neurons (28% of total recorded cells) that increase their firing rates during periods of ‘eye-closure’ and sleep. This suggests that identified areas of monkey mPFC are part of the anterior ‘default mode network’.

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