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Susana Peciña and Kent C. Berridge Dopamine or opioid stimulation of nucleus accumbens similarly amplify cue-triggered ‘wanting’ for reward: entire core and medial shell mapped as substrates for PIT enhancement European Journal of Neuroscience 37

Article first published online: 17 MAR 2013 | DOI: 10.1111/ejn.12174

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Surges in the level of motivation elicited by reward cues (i.e., changes cue-triggered ‘wanting’) are mediated by opioid and-or dopamine stimulations that increase reactivity of mesocorticolimbic brain circuits involving the nucleus accumbens, which dynamically compute incentive salience for a cue. Nearly the entire medial shell and the entire core can similarly mediate dopamine and opioid enhancements.

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