J. Flygt, A. Djupsjö, F. Lenne and N. Marklund Myelin loss and oligodendrocyte pathology in white matter tracts following traumatic brain injury in the rat European Journal of Neuroscience
White matter injury is common following traumatic brain injury and may lead to reduced functional connectivity and impaired cognitive function. In two widely used models of traumatic brain injury, axonal injury, demyelination, oligodendrocyte death and oligodendrocyte precursor changes were evaluated. Brain injury caused widespread demyelination and axon injury, accompanied by apoptotic oligodendrocytes and an increased number of oligodendrocyte progenitors in white matter tracts.
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