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Gale A. Kleven, Priyanka Joshi, Marco Voogd and April E. Ronca Prenatal ontogeny of the dopamine-dependent neurobehavioral phenotype in Pitx3-deficient mice European Journal of Neuroscience 37

Article first published online: 13 MAR 2013 | DOI: 10.1111/ejn.12184

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Across the last four days of gestation, Pitx3 mutants showed significantly increased latencies to exhibit Facial Wiping response to oral/tactile stimulation as compared to both heterozygous and C57BL/6J controls. These findings provide evidence that the primary fetal neurobehavioral deficit of the Pitx3 mutation is akinesia related to nigrostriatal damage. These results further demonstrate the sensitivity of fetal neurobehavioral assessments in the detection of emerging neural dysfunction, suggesting utility for prenatal diagnosis.

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