Sirin Korulu, Aysegul Yildiz-Unal, Meral Yuksel and Arzu Karabay Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons European Journal of Neuroscience 37
We investigated the role of PKC on cyclinD1 regulation in hippocampal neurons and found that PKC activation increased nuclear cyclinD1 and PKC-α, but not PKC-ε. Moreover, nuclear PKC-α and cyclinD1 interfered with differentiation by promoting microtubule re-organisation via changing p60- katanin, p53 levels and phosphorylation status of tau and pRb. Relationship of the cell cycle in postmitotic neurons is a compelling irony that may have important roles in both development and differentiation.
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