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Sirin Korulu, Aysegul Yildiz-Unal, Meral Yuksel and Arzu Karabay Protein kinase C activation causes neurite retraction via cyclinD1 and p60-katanin increase in rat hippocampal neurons European Journal of Neuroscience 37

Article first published online: 15 MAR 2013 | DOI: 10.1111/ejn.12185

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We investigated the role of PKC on cyclinD1 regulation in hippocampal neurons and found that PKC activation increased nuclear cyclinD1 and PKC-α, but not PKC-ε. Moreover, nuclear PKC-α and cyclinD1 interfered with differentiation by promoting microtubule re-organisation via changing p60- katanin, p53 levels and phosphorylation status of tau and pRb. Relationship of the cell cycle in postmitotic neurons is a compelling irony that may have important roles in both development and differentiation.

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