Tomoyuki Miyazaki, Misako Kunii, Susumu Jitsuki, Akane Sano, Yoshiyuki Kuroiwa and Takuya Takahashi Social isolation perturbs experience-driven synaptic glutamate receptor subunit 4 delivery in the developing rat barrel cortex European Journal of Neuroscience 37
We recently reported that early social isolation disrupts experience-driven GluA1 delivery to layer 4-2/3 pyramidal synapses during P12-14. Here, we report that neonatal isolation impacts even earlier stages of development by preventing experience-dependent synaptic GluA4 delivery. Thus, social isolation severely affects synaptic maturation throughout early postnatal development.
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