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Angela Orth, Daniel Tapken and Michael Hollmann The delta subfamily of glutamate receptors: characterization of receptor chimeras and mutants European Journal of Neuroscience 37

Version of Record online: 31 MAR 2013 | DOI: 10.1111/ejn.12193

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Based on sequence homology, the delta receptors, GluD1 and GluD2, are regarded as a subfamily of the ionotropic glutamate receptors (iGluRs). However, they have not been shown to respond to glutamatergic agonists. We demonstrate that both delta receptors have functional gating machineries and ion permeation pathways similar but not identical to those of other iGluRs. The key differences between delta receptors and other iGluRs appear to be located within the ligand binding domain.

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