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Subhash C. Gupta, Brandon G. Hillman, Anand Prakash, Rajesh R. Ugale, Dustin J. Stairs and Shashank M. Dravid Effect of D-cycloserine in conjunction with fear extinction training on extracellular signal-regulated kinase activation in the medial prefrontal cortex and amygdala in rat European Journal of Neuroscience 37

Article first published online: 31 MAR 2013 | DOI: 10.1111/ejn.12197

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The major finding of our study is that D-cycloserine facilitates the fear extinction by enhancing synaptic plasticity in infralimbic prefrontal cortex and specific subnuclei in the amygdala, specifically the intercalated neurons and lateral subdivision of central amygdala. Our findings suggest that the efficacy of DCS in neuropsychiatric disorders may be partly due to its ability to selectively affect neuronal activity and signaling in the mPFC and amygdala subnuclei.

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