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Michaela Fredrich, Anne C. Zeber, Heika Hildebrandt and Robert-Benjamin Illing Differential molecular profiles of astrocytes in degeneration and re-innervation after sensory deafferentation of the adult rat cochlear nucleus European Journal of Neuroscience 38

Article first published online: 15 APR 2013 | DOI: 10.1111/ejn.12200

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Ablating the cochlea of adult rats causes a total sensory deafferentation of the cochlear nucleus. Degeneration of the auditory nerve and its synaptic terminals temporally overlaps with the formation of new synapses in the cochlear nucleus. We show that the process of establishing new synaptic contacts prompts astrocytes to recompose their molecular profile, indicating that they are an integral component of a lesion-induced re-organisation in the adult brain.

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