Geraldine T. Petr, Laurel A. Schultheis, Kayla C. Hussey, Yan Sun, Janet M. Dubinsky, Chiye Aoki and Paul A. Rosenberg Decreased expression of GLT-1 in the R6/2 model of Huntington's disease does not worsen disease progression European Journal of Neuroscience 38
Excitotoxicity is thought to be important in the pathogenesis of Huntington's disease (HD). Glutamate is the predominant excitatory neurotransmitter in the brain and excess activation of glutamate receptors can cause neuronal dysfunction and death. GLT-1 is the most abundant glutamate transporter, and here we show it is expressed in both excitatory terminals and astrocytes in the striatum. Our results suggest that changes in GLT-1 expression or function per se are unlikely to potentiate or ameliorate HD progression.
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