Ingrid Morales, Magdalena Sabate and Manuel Rodriguez Striatal glutamate induces retrograde excitotoxicity and neuronal degeneration of intralaminar thalamic nuclei: their potential relevance for Parkinson's disease European Journal of Neuroscience 38
The striatal decrease of dopamine increased the extracelular glutamate pool. The glutamatergic thalamo-striatal pathway degenerated with the striatal increase of glutamate. Present data in rats suggest that glutamatergic hyperactivity in the striatum could be the cause of a retrograde degeneration of the intralaminar thalamic nuclei in Parkinson's disease.
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