Christopher D. Howard, David P. Daberkow, Eric S. Ramsson, Kristen A. Keefe and Paul A. Garris Methamphetamine-induced neurotoxicity disrupts naturally occurring phasic dopamine signaling European Journal of Neuroscience 38
Methamphetamine (METH) neurotoxicity leads to long-term damage to brain dopamine (DA) systems. Here we demonstrate that METH-induced DA depletion causes deficits in phasic DA signaling, which is important to reward-based learning, in freely-moving rats. This is the first report identifying deficits in naturally occurring phasic DA signaling in any DA-denervation model, and these deficits may serve as a mechanistic link between DA depletion and cognitive impairments associated with METH abuse.
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