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Fernando H. F. Alves, Felipe V. Gomes, Daniel G. Reis, Carlos C. Crestani, Fernando M. A. Corrêa, Francisco S. Guimarães and Leonardo B. M. Resstel Involvement of the insular cortex in the consolidation and expression of contextual fear conditioning European Journal of Neuroscience 38

Article first published online: 11 APR 2013 | DOI: 10.1111/ejn.12210

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The IC microinjection of CoCl2, either after the conditioning session or before the test session, attenuated the behavioral (freezing) and cardiovascular responses evoked by the re-exposure to an aversively conditioned context. However, the inactivation of the IC did not impair the acquisition of the contextual fear memory when CoCl2 was microinjected before the conditioning session. These results suggest the involvement of IC in both the consolidation and expression of contextual fear memory.

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