Lyndsey E. Collins-Praino, Nicholas E. Paul, Felicia Ledgard, Samantha J. Podurgiel, Rotem Kovner, Younis Baqi, Christa E. Müller, Patrick B. Senatus and John D. Salamone Deep brain stimulation of the subthalamic nucleus reverses oral tremor in pharmacological models of parkinsonism: interaction with the effects of adenosine A2A antagonism European Journal of Neuroscience 38
The tremulous jaw movement (TJM) model was used to study the effects of subthalamic (STN) deep brain stimulation (DBS) in rats. STN DBS reduced the TJMs induced by dopamine antagonists and cholinomimetic drugs. The ability of DBS to suppress TJMs was dependent upon the neuroanatomical locus being stimulated, and the frequency and intensity of stimulation used. Administration of the adenosine A2A receptor antagonist MSX-3 reduced the frequency and intensity parameters needed to reduce TJMs.
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