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Carl J. L. Sogn, Maja Puchades and Vidar Gundersen Rare contacts between synapses and microglial processes containing high levels of Iba1 and actin – a postembedding immunogold study in the healthy rat brain European Journal of Neuroscience 38

Article first published online: 17 APR 2013 | DOI: 10.1111/ejn.12213

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In order to influence synaptic communication microglia move in the neuropil and contact synapses. By immunogold electron microscopy we here show that at a given time point direct interaction between microglia and synapses in the brain is rather infrequent. However, the most delicate microglial processes, which are the ones that contact synapses, are equipped with high levels of Iba1 and actin, enabling them to move in the neuropil.

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