Christopher C. Lay, Nathan Jacobs, Aneeka M. Hancock, Yi Zhou and Ron D. Frostig Early stimulation treatment provides complete sensory-induced protection from ischemic stroke under isoflurane anesthesia European Journal of Neuroscience 38
Using a rat model of ischemia (permanent middle cerebral artery occlusion; pMCAO) we demonstrate that whisker stimulation can completely protect the cortex from impending stroke. Furthermore, the broad extent of evoked activity evident under isoflurane anesthesia plays a significant role in the protection from, or deterioration towards infarct. We conclude that the pMCAO model may be carried out using isoflurane, allowing for the future investigation of ischemic stroke in awake animals.
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