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Neus Garcia, Mercedes Priego, Teresa Obis, Manel M. Santafe, Marta Tomàs, Nuria Besalduch, MªAngel Lanuza and Josep Tomàs Adenosine A1 and A2A receptor-mediated modulation of acetylcholine release in the mice neuromuscular junction European Journal of Neuroscience 38

Article first published online: 22 APR 2013 | DOI: 10.1111/ejn.12220

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Immunocytochemistry shows that purinergic receptors A1R and A2AR are present in the nerve endings at the mouse neuromuscular junction. Electrophysiology in µ-CgTx-GIIIB paralyzed muscles show that the receptors might have no real effect on neuromuscular transmission in resting conditions. However, these receptors can conserve resources by limiting spontaneous quantal leak of ACh (mainly A1Rs) and may protect synaptic function by reducing the magnitude of depression during repetitive activity.

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