Yong Yu and Melitta Schachner Syntenin-a promotes spinal cord regeneration following injury in adult zebrafish European Journal of Neuroscience 38
Syntenin-a is upregulated caudal to the lesion site following spinal cord injury in adult zebrafish. Knock-down syntenin-a expression by morpholino resulted in inhibition of locomotor recovery and regrowth of axons from brain. These observations indicate that syntenin-a is involved in central nervous system regeneration, potentially leading to novel insights into the cellular and molecular mechanisms that may be require activation in the regeneration-deficient mammalian central nervous system.
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