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P. G. R. Burke, L. O. Sousa, V. J. Tallapragada and A. K. Goodchild Inhibition of protein kinase A activity depresses phrenic drive and glycinergic signalling, but not rhythmogenesis in anaesthetized rat European Journal of Neuroscience 38

Article first published online: 29 APR 2013 | DOI: 10.1111/ejn.12230

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We describe the role of endogenous Protein Kinase A (PKA) signalling in vivo in shaping the population activity of respiratory neurons that regulate respiratory rhythm and motor patterns. We identify two key functions of PKA activity: (i) potentiating inspiratory drive currents of prebötzinger neurons and phrenic premotor neurons that regulate the intensity of phrenic nerve discharge, and (ii) potentiating glycinergic transmission that restrains the frequency of rhythmic respiratory activity.

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