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Sara Ailane, Philip Long, Peter Jenner and Sarah Rose Expression of integrin and CD44 receptors recognising osteopontin in the normal and LPS-lesioned rat substantia nigra European Journal of Neuroscience 38

Version of Record online: 22 MAY 2013 | DOI: 10.1111/ejn.12231

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Integrin and CD44 receptors, that mediate actions of the potential neuroprotective protein OPN in the periphery, are expressed on dopaminergic neurons of the SN and interact with OPN in the brain. Following inflammation, the expression of these receptors is up-regulated and they are expressed on inflammatory cells implicating a role in regulating the inflammatory process in the SN and thus a potential target for neuroprotection in PD.

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