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Yury M. Morozov, Martin H. Dominguez, Luis Varela, Marya Shanabrough, Marco Koch, Tamas L. Horvath and Pasko Rakic Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria European Journal of Neuroscience 38

Article first published online: 26 APR 2013 | DOI: 10.1111/ejn.12237

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We found that anti-CB1 sera, in parallel to CB1, also recognize the mitochondrial protein stomatin-like protein 2. In addition, we show that the previously reported effect of synthetic cannabinoid WIN 55,212-2 on mitochondrial complex III respiration is not detectable in purified mitochondrial preparations. Thus, our study indicates that a direct relationship between endocannabinoid signaling and mitochondrial functions in the cerebral cortex seems unlikely and that caution should be taken interpreting findings obtained using anti-CB1 antibodies.

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