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James M. Krueger, Yanhua H. Huang, David M. Rector and Daniel J. Buysse Sleep: a synchrony of cell activity-driven small network states European Journal of Neuroscience 38

Version of Record online: 8 MAY 2013 | DOI: 10.1111/ejn.12238

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A theory positing that sleep is initiated within small local neuronal networks is presented. Sleep-like states occur in small networks such as cortical columns and the biochemical events responsible include sleep regulatory substances. The activity-dependent local sleep mechanisms are associated with changes in receptor trafficking and provide an explanation for clinical phenomena such as sleep inertia and sleep disorders such as insomnia.

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