Rebecca S. Lam and Peter Mombaerts Odorant responsiveness of embryonic mouse olfactory sensory neurons expressing the odorant receptors S1 or MOR23 European Journal of Neuroscience 38
We report patch-clamp recordings from embryonic mouse olfactory sensory neurons that express the odorant receptor gene S1 or MOR23, using the odorous ligands 2-phenylethyl alcohol or lyral. We identify E16.5 as the upper limit of the acquisition of odorant responsiveness by these neuronal populations. The S1 and MOR23 glomeruli in the olfactory bulb are formed postnatally. These neuronal populations can thus respond to a cognate odorant several days before their axons coalesce into glomeruli.
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