R. Mychasiuk, A. Muhammad, C. Carroll and B. Kolb Does prenatal nicotine exposure alter the brain's response to nicotine in adolescence? A neuroanatomical analysis European Journal of Neuroscience 38
Prenatal nicotine exposure has been associated with many negative outcomes including increased risk for nicotine addiction in adulthood. In this study we examined neuroanatomical changes that occurred in response to nicotine exposure in the prenatal period and in adolescence. Although combined exposure to nicotine at both time points was rarely additive; nicotine administration in adolescence profoundly altered neuronal morphology and synaptic plasticity in the brain regions examined.
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