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Milena V. Deolindo, Daniel G. Reis, Carlos C. Crestani, Rodrigo F. Tavares, Leonardo B. M. Resstel and Fernando M. A. Corrêa NMDA receptors in the lateral hypothalamus have an inhibitory influence on the tachycardiac response to acute restraint stress in rats European Journal of Neuroscience 38

Version of Record online: 13 MAY 2013 | DOI: 10.1111/ejn.12246

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The bilateral microinjection of the CoCl2 or LY235959 into the LH enhanced the HR increase evoked by restraint stress without affecting the blood pressure increase. Intravenous administration of the homatropine methyl bromide abolished the changes in cardiovascular responses to restraint stress following LH treatment with LY235959.

These results suggest that such LH influence is mediated by local NMDA glutamate receptors and involves parasympathetic nervous activation.

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