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Andrea C. LeBlanc Caspase-6 as a novel early target in the treatment of Alzheimer's disease European Journal of Neuroscience 37

Version of Record online: 16 JUN 2013 | DOI: 10.1111/ejn.12250

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Caspase-6 activity is intimately associated with Alzheimer Disease pathological hallmarks and cognitive impairment. The action of Caspase-6 results in the proteolysis of several neuronal proteins that could affect in parallel many cellular functions. This paper summarizes the evidence for Caspase-6 in Alzheimer Disease and examines the possibility that inhibiting Caspase-6 may provide an efficient treatment against early cognitive impairment and progression to dementia in Alzheimer Disease.

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