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Michael A. McDannald, Barry Setlow and Peter C. Holland Effects of ventral striatal lesions on first- and second-order appetitive conditioning European Journal of Neuroscience 38

Article first published online: 20 MAY 2013 | DOI: 10.1111/ejn.12255

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Rats with bilateral lesions of the ventral striatal nucleus accumbens failed to acquire Pavlovian second-order conditioning to auditory stimuli paired with visual stimuli that had previously received first-order pairings with food. This deficit in second-order conditioning was specific to learning driven by incentive properties of the first-order cues, and was observed whether the first-order training had occurred prior to or after lesion surgery.

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