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Feng Yi, Shu-Su Liu, Fei Luo, Xue-Han Zhang and Bao-Ming Li Signaling mechanism underlying α2A-adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats European Journal of Neuroscience 38

Version of Record online: 23 MAY 2013 | DOI: 10.1111/ejn.12257

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Activation of α2A-adrenergic receptors suppresses excitatory synaptic transmission by postsynaptic mechanism. The inhibitory effect of α2A-adrenergic receptors activation is mediated mainly via Gi-cAMP-PKA-PP1-CaMKII-AMPAR pathway. This finding provides important information on acute neuromodulation of neocortical circuits, which may play roles in regulating cortical function.

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