Feng Yi, Shu-Su Liu, Fei Luo, Xue-Han Zhang and Bao-Ming Li Signaling mechanism underlying α2A-adrenergic suppression of excitatory synaptic transmission in the medial prefrontal cortex of rats European Journal of Neuroscience 38
Activation of α2A-adrenergic receptors suppresses excitatory synaptic transmission by postsynaptic mechanism. The inhibitory effect of α2A-adrenergic receptors activation is mediated mainly via Gi-cAMP-PKA-PP1-CaMKII-AMPAR pathway. This finding provides important information on acute neuromodulation of neocortical circuits, which may play roles in regulating cortical function.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf