Mouna Maroun, Pericles J. Ioannides, Krista L. Bergman, Alexandra Kavushansky, Andrew Holmes and Cara L. Wellman Fear extinction deficits following acute stress associate with increased spine density and dendritic retraction in basolateral amygdala neurons European Journal of Neuroscience 38
Acute stress impaired extinction (A) and produced dendritic retraction in basolateral amygdala (BLA) pyramidal neurons (B). Stress-induced changes in morphology were lateralized to the right hemisphere, whereas behavioral testing produced dendritic retraction in the left hemisphere (C). Right-hemisphere dendritic retraction correlated with extinction deficits (D). Thus, learning and stress produced dissociable changes in BLA morphology. BLA dendritic and synaptic remodeling could contribute to stress-induced impairments in extinction and stress-related disorders.
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