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Lukasz Piszczek, Kevin Schlax, Anna Wyrzykowska, Agnieszka Piszczek, Enrica Audero and Cornelius Thilo Gross Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice European Journal of Neuroscience 38

Article first published online: 22 MAY 2013 | DOI: 10.1111/ejn.12260

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Mice lacking the serotonin 1A receptor (Htr1a) show elevated avoidance of novel open spaces, suggesting that this receptor plays a role in modulating anxiety behavior. Here we show that mice carrying a transgene rescuing receptor expression exclusively in serotonin neurons (Htr1aRR mice) were not able to restore wild-type anxiety behavior. These findings can be reconciled if Htr1a autoreceptors and heteroreceptors modulate anxiety in a manner that depends on each other.

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