Lukasz Piszczek, Kevin Schlax, Anna Wyrzykowska, Agnieszka Piszczek, Enrica Audero and Cornelius Thilo Gross Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice European Journal of Neuroscience 38
Mice lacking the serotonin 1A receptor (Htr1a) show elevated avoidance of novel open spaces, suggesting that this receptor plays a role in modulating anxiety behavior. Here we show that mice carrying a transgene rescuing receptor expression exclusively in serotonin neurons (Htr1aRR mice) were not able to restore wild-type anxiety behavior. These findings can be reconciled if Htr1a autoreceptors and heteroreceptors modulate anxiety in a manner that depends on each other.
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