Nirnath Sah and Sujit K. Sikdar Transition in subicular burst firing neurons from epileptiform activity to suppressed state by feedforward inhibition European Journal of Neuroscience 38
Induction of epileptic activity is characterized by several fast and slow temporal transitions due to intrinsic and extrinsic mechanisms. Subiculum gates information from the hippocampus to the entorhinal cortex. We demonstrate the transition from an epileptic state to suppressed state in subicular pyramidal neurons in brain slice upon prolonged epileptogenic stimulus and ascribe it to the feedforward inhibition where local fast spiking interneurons may be involved in phasic and tonic inhibition.
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