Kazuki Obashi and Shigeo Okabe Regulation of mitochondrial dynamics and distribution by synapse position and neuronal activity in the axon European Journal of Neuroscience 38
We measured stability and mobility of axonal mitochondria by using time-lapse imaging of cultured hippocampal neurons. We found that both stability of stationary mitochondria and probability to pause near presynaptic sites are regulated by developmental stages and neuronal activity. Our results provide a detailed framework for understanding how neuronal maturation, activity and synaptic location dynamically determine the distribution of mitochondria along the axon.
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