Mark J. Ferris, Erin S. Calipari, James R. Melchior, David C. S. Roberts, Rodrigo A. España and Sara R. Jones Paradoxical tolerance to cocaine after initial supersensitivity in drug-use-prone animals European Journal of Neuroscience 38
There is great interest in outlining biological factors and behavioral characteristics that either predispose or predict vulnerability to substance use disorders. We used cocaine self-administration under a fixed-ratio one schedule followed by fast scan cyclic voltammetry in brain slices to measure sub-second DA release and uptake parameters in drug-use prone and resistant phenotypes. We show a supersensitivity in the ability of cocaine to inhibit dopamine uptake following acute administration in animals with higher locomotor response to a novel environment. Following a history of cocaine self-administration, however, tolerance in the ability of cocaine to inhibit dopamine uptake coexists with a behavioral phenotype that is defined by increased preoccupation with cocaine as measured by rapid acquisition and early high intake.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf