Marie-Krystel Gauthier, Kamilla Kosciuczyk, Laura Tapley and Soheila Karimi-Abdolrezaee Dysregulation of the neuregulin-1–ErbB network modulates endogenous oligodendrocyte differentiation and preservation after spinal cord injury European Journal of Neuroscience 38
Neuregulin-1 (Nrg-1) and ErbB receptors modulate several aspects of oligodendrocyte biology including differentiation and myelination. In rat spinal cord injury (SCI), we found a rapid and sustained downregulation of Nrg-1 that is correlated with the poor replacement of oligodendrocytes and remyelination seen after SCI. We show that increasing the bio-availability of Nrg-1 after SCI augments the generation of new oligodendrocytes while reducing scar forming astrocytes. Our work suggests a potential for Nrg-1 as a therapeutic target for promoting remyelination following SCI.
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