Maik M. A. Worlitzer, Thomas Viel, Andreas H. Jacobs and Jens C. Schwamborn The majority of newly generated cells in the adult mouse substantia nigra express low levels of Doublecortin, but their proliferation is unaffected by 6-OHDA-induced nigral lesion or Minocycline-mediated inhibition of neuroinflammation European Journal of Neuroscience 38
The majority of newly generated cells in the substantia nigra are positive for Doublecortin (Dcx). Generation of this cells is independent from Parkinson's disease associated neuronal degeneration and accompanying neuroinflammation. Importantly, there is no evidence that these Dcx positive cells differentiate into neurons or oligodendrocytes, consequently they seem to represent a novel cell type.
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