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Meagan L. Auger, Ewoud R. E. Schmidt, Colleen Manitt, Greg Dal-Bo, R. Jeroen Pasterkamp and Cecilia Flores unc5c haploinsufficient phenotype: striking similarities with the dcc haploinsufficiency model European Journal of Neuroscience 38

Version of Record online: 5 JUN 2013 | DOI: 10.1111/ejn.12270

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Here we demonstrate selective expression of unc5 homolog c mRNA by dopamine neurons in adulthood and show that adult mice that develop with reduced UNC5C protein exhibit an increase in mPFC tyrosine hydroxylase expression, selectively, and protection against amphetamine-induced locomotion, but only after adolescence.

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