Rebecca R. Fanelli, Jeffrey T. Klein, Rebecca M. Reese and Donita L. Robinson Dorsomedial and dorsolateral striatum exhibit distinct phasic neuronal activity during alcohol self-administration in rats European Journal of Neuroscience 38
To examine the role of dorsal striatal subregions in alcohol-motivated behavior, we recorded neuronal activity in rats self-administering alcohol on different reinforcement schedules that produced goal-directed or habitual behavior. Dorsomedial striatum preferentially responded to alcohol-associated cues, while dorsolateral responses were more associated with motor output. This distinction was diminished in habit-trained rats, which may be a neurophysiologic reflection of habitual behavior.
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