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Stefanie M. Klampfl, Inga D. Neumann and Oliver J. Bosch Reduced brain corticotropin-releasing factor receptor activation is required for adequate maternal care and maternal aggression in lactating rats European Journal of Neuroscience 38

Version of Record online: 7 JUN 2013 | DOI: 10.1111/ejn.12274

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In lactating rats, either bred for extremes in anxiety or non-selected, activating brain CRF receptors with CRF reduced maternal care under basal conditions and impaired maternal aggression while blocking CRF receptors with D-Phe improved the stress-induced impairment of maternal care and reduced anxiety. Thus, reduced activation of brain CRF receptors is a necessary prerequisite for the expression of appropriate maternal care and aggression as well as for attenuated anxiety in lactation.

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