Alberto Camacho, Jeffrey K. Huang, Ilse Delint-Ramirez, Chong Yew Tan, Maria Fuller, Christopher J. Lelliott, Antonio Vidal-Puig and Robin J. M. Franklin Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha coordinates sphingolipid metabolism, lipid raft composition and myelin protein synthesis European Journal of Neuroscience 38
Peroxisome proliferator-activated receptor gamma-coactivator-1 alpha (PGC1a) is involved in energy and lipid metabolism, and its loss leads to neurodegeneration. Ablation of PGC1a increased phosphatidylcholine and decreased ceramides in the brain. An analysis of lipid raft fractions revealed increased ceramide, glucocylceramides and GM1 ganglioside in the PGC1a mutants. We suggest that PGC1a coactivator coordinates brain age-dependent sphingolipid metabolism and oligodendrocyte differentiation.
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