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Yves Boucher, Rufino Felizardo, Amanda H. Klein, Mirela I. Carstens and Earl Carstens Gustatory modulation of the responses of trigeminal subnucleus caudalis neurons to noxious stimulation of the tongue in rats European Journal of Neuroscience 38

Article first published online: 27 JUN 2013 | DOI: 10.1111/ejn.12282

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Lingual application of monosodium glutamate (MSG) and NaCl inhibited nociceptive responses of trigeminal subnucleus caudalis (Vc) neurons in a manner not requiring intact gustatory nerves (chorda tympani = CT). Neither MSG, NaCl nor γ-aminobutyric acid (GABA) affected noxious chemically-evoked responses of trigeminal ganglion cells. We speculate that MSG and NaCl excite type I/II taste receptor cells that release ATP to excite type III (presynaptic) taste receptor cells, which in turn excite CT fibers via 5-HT and also release some mediator other than GABA that inhibits nearby perigemmal trigeminal nociceptive nerve endings.

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