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Juan Manuel Gutierrez-Garralda, Pablo Moreno-Briseño, Marie-Catherine Boll, Consuelo Morgado-Valle, Aurelio Campos-Romo, Rosalinda Diaz and Juan Fernandez-Ruiz The effect of Parkinson's disease and Huntington's disease on human visuomotor learning European Journal of Neuroscience 38

Article first published online: 27 JUN 2013 | DOI: 10.1111/ejn.12288

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Error-based learning models cannot fully explain human visuomotor learning. (A) We have suggested that it can be dissociated in one dependent on error signal feedback and another that can lead to improvement without using the error signal. Here we tested in Huntington's disease and Parkinson's disease patients if basal ganglia lesions disrupt non-error based sensorimotor learning while leaving error-based learning unaffected. (B) The results show a dissociation between their normal performance on error-based learning and the impaired performance on the non-error based learning.

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