Sabine Ladrech, Marc Mathieu, Jean-Luc Puel and Marc Lenoir Supporting cells regulate the remodelling of aminoglycoside-injured organ of Corti, through the release of high mobility group box 1 European Journal of Neuroscience 38
When the organ of Corti was poisoned by an aminoglycoside antibiotic, supporting cells named Deiters cells released the damage signal HMGB1 in response to hair cell degeneration. HMGB1 probably promoted chemoattraction of adjacent epithelial cells towards the site of initial damage through receptor RAGE engagement. This study underscores the major role of supporting cells and HMGB1 in orchestrating the remodelling of a sensory organ after drug poisoning.
Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf