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Sabine Ladrech, Marc Mathieu, Jean-Luc Puel and Marc Lenoir Supporting cells regulate the remodelling of aminoglycoside-injured organ of Corti, through the release of high mobility group box 1 European Journal of Neuroscience 38

Version of Record online: 8 JUL 2013 | DOI: 10.1111/ejn.12290

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When the organ of Corti was poisoned by an aminoglycoside antibiotic, supporting cells named Deiters cells released the damage signal HMGB1 in response to hair cell degeneration. HMGB1 probably promoted chemoattraction of adjacent epithelial cells towards the site of initial damage through receptor RAGE engagement. This study underscores the major role of supporting cells and HMGB1 in orchestrating the remodelling of a sensory organ after drug poisoning.

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