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Ryo Kurosawa, Naofumi Taoka, Fumiya Shinohara, Masabumi Minami and Katsuyuki Kaneda Cocaine exposure enhances excitatory synaptic drive to cholinergic neurons in the laterodorsal tegmental nucleus European Journal of Neuroscience 38

Article first published online: 3 JUL 2013 | DOI: 10.1111/ejn.12296

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We found that cholinergic neurons in the laterodorsal tegmental nucleus (LDT), which innervate to the ventral tegmental area dopamine neurons, exhibit presynaptic plasticity following repeated cocaine exposure. The plasticity depends on NMDA receptor stimulation, NO production, and medial prefrontal cortical activity. The findings suggest that plasticity-induced enhancement of LDT neuronal activity may contribute to triggering cocaine-induced addictive behaviors.

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