Silvina L. Diaz, Nicolas Narboux-Nême, Sara Trowbridge, Sophie Scotto-Lomassese, Felix B. Kleine Borgmann, Sebastian Jessberger, Bruno Giros, Luc Maroteaux, Evan Deneris and Patricia Gaspar Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin European Journal of Neuroscience 38
Although increased adult neurogenesis is a neurobiological correlate of the beneficial effects of antidepressants, the consequences of 5-HT depletion are still unclear. We analysed 2 genetic models and a pharmacological model of 5-HT depletion. In all models, including the Pet1-KO mice, we found significant increase in the survival of newborn neurons. Administration of the 5-HT1A receptor agonist 8-OH-DPAT normalised this prosurvival effects. Our results indicate a role of 5-HT in selective neuronal elimination.
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