E-mail

E-mail a Wiley Online Library Link

Silvina L. Diaz, Nicolas Narboux-Nême, Sara Trowbridge, Sophie Scotto-Lomassese, Felix B. Kleine Borgmann, Sebastian Jessberger, Bruno Giros, Luc Maroteaux, Evan Deneris and Patricia Gaspar Paradoxical increase in survival of newborn neurons in the dentate gyrus of mice with constitutive depletion of serotonin European Journal of Neuroscience 38

Article first published online: 10 JUL 2013 | DOI: 10.1111/ejn.12297

Thumbnail image of graphical abstract

Although increased adult neurogenesis is a neurobiological correlate of the beneficial effects of antidepressants, the consequences of 5-HT depletion are still unclear. We analysed 2 genetic models and a pharmacological model of 5-HT depletion. In all models, including the Pet1-KO mice, we found significant increase in the survival of newborn neurons. Administration of the 5-HT1A receptor agonist 8-OH-DPAT normalised this prosurvival effects. Our results indicate a role of 5-HT in selective neuronal elimination.

Complete the form below and we will send an e-mail message containing a link to the selected article on your behalf

Required = Required Field

SEARCH