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Richard Exley, Michael A. Clements, Henrike Hartung, J. Michael McIntosh, Michael Franklin, Isabel Bermudez and Stephanie J. Cragg Striatal dopamine transmission is reduced after chronic nicotine with a decrease in α6-nicotinic receptor control in nucleus accumbens European Journal of Neuroscience 38

Version of Record online: 10 JUL 2013 | DOI: 10.1111/ejn.12298

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Chronic nicotine exposure for 2 months slightly modifies dopamine (DA) release probability across striatum and modifies its activity dependence in nucleus accumbens (NAc). In NAc, the control of DA release by the dominant α6α4β2β3 subtype of nicotinic receptor (nAChR) is attenuated in favour of α4(nonα6)β2 nAChRs. The balance of control by α6β2 vs. α4(nonα6)β2 nAChRs in CPu however, is unchanged. Changes to α6α4β2β3 control of DA transmission in NAc may contribute to nicotine addiction.

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