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Hermann A. Rodrigues, Ricardo F. Lima, Matheus de C. Fonseca, Ernani A. Amaral, Patrícia M. Martinelli, Lígia A. Naves, Marcus V. Gomez, Christopher Kushmerick, Marco A. M. Prado and Cristina Guatimosim Membrane cholesterol regulates different modes of synaptic vesicle release and retrieval at the frog neuromuscular junction European Journal of Neuroscience 38

Article first published online: 10 JUL 2013 | DOI: 10.1111/ejn.12300

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We investigated the effect of cholesterol removal by MβCD in synaptic vesicle recycling at motor nerve terminals of the frog neuromuscular junction. Our data shows that membrane cholesterol acts on the modulation of synaptic vesicle cycle and seems to be essential for the balance between KCl-evoked and spontaneous release. In addition, we provide evidences that deregulation of cholesterol affects synaptic vesicle biogenesis with consequences for increased transmitter packing.

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